Pericardial Mesothelioma

Pericardial mesothelioma is a rare form of mesothelioma that accounts for roughly 5% of all mesothelioma cases. Pericardial mesothelioma is a cancer that grows on the lining of the heart. The lining of the heart is extremely important because it plays an important role in protecting the heart from damage and so pericardial mesothelioma is an extremely serious condition. Pericardial mesothelioma becomes a terminal illness if not treated aggressively in its early stages.

Like all other forms of mesothelioma, pericardial mesothelioma is caused by inhalation of asbestos dust and fibres. Once inhaled, asbestos fibres become lodged in the lungs. From the lungs, the fibres can either pass into the lymphatic system and then be transported to the lining of the lungs or they can gradually move across to the lining of the heart over a long period of time. Over a long period of time, asbestos fibres can accumulate on the lining of the heart and this is when pericardial mesothelioma becomes a likelihood. Due to the fact that asbestos is still present in many public buildings, the possibility of pericardial mesothelioma is a reality for everyone, although for most, very unlikely.

Those with the highest chance of having mesothelioma are those who have been in constant contact with mesothelioma for a length of time as short as a few months. These are people like construction workers and asbestos manufacturers. Those who are in contact with people who are constantly exposed to asbestos are also at risk due to the fact that asbestos fibres can stick to clothes and hair and so can be carried around.

Presently, cases of mesothelioma are increasing including pericardial mesothelioma. Elderly men who are approaching 60 - 70 years of age are just starting to suffer from pericardial mesothelioma due to its long latency period (amount of time the symptoms take to show) of 30 - 50 years. They are suffering because this was the generation who worked with asbestos and amongst asbestos when asbestos was an extremely popular building material in the 1950s – 1970s. These men are now lodging multi-million dollar lawsuits against the companies who exposed them to the dangers of asbestos.

Pericardial mesothelioma has a number of symptoms but these only start to take effect in the cancer’s latest stages when it is almost fully matured and developed. These symptoms include persistent coughing, shortness of breath, chest pains and palpitations. Other symptoms typical of all types of mesothelioma include loss of appetite, nausea and weight loss. What often makes pericardial mesothelioma so difficult to treat is that its symptoms are typical of many other more common diseases such as pneumonia. To be treated effectively, pericardial mesothelioma needs to be treated aggressively in its early stages and so many patients’ treatments are given too late because of a delay in diagnosis.

Treatments for pericardial mesothelioma are very limited and as yet, success rates for curing pericardial mesothelioma are very low. The chances of a patient’s survival depend largely on how early the cancer is treated and how aggressively. Treatment methods include chemotherapy, radiation therapy, dual therapy and surgery. Chemotherapy uses drugs to try to kill off cancerous cells. Radiation therapy uses radiation to try to kill off cancerous cells although this is extremely difficult in the case of pericardial mesothelioma because too much radiation can badly damage the heart.

Dual therapy is a combination of both chemotherapy and radiation therapy. Surgery comes in two different types, aggressive surgery and palliative procedures. Aggressive surgery is only used on the strongest of patients such as young and healthy men and consists of removing a large portion of the cancer and attempts to gain control over the cancer. Palliative procedures are a more passive way of dealing with pericardial mesothelioma and just attempts to relieve the patient of the symptoms.

Research is being done into pericardial mesothelioma in research stations all over the USA and many pharmaceutical companies are also attempting to find new drugs for chemotherapy. So far, much research has been unsuccessful.

Mesothelioma Lung

Asbestos is the single biggest work place killer today. People who have worked with the material are at serious risk from developing lung cancer, asbestosis and mesothelioma, fatal respiratory illnesses that debilitate their victims. Evidence of asbestos’ deadly effect on those who breathe its fibres is likely to multiply in the decades to come.

Asbestos was once heralded as the greatest building material available to those in the construction industries. Its high tensile strength, durability and flexibility, as well as heat insulation and fire retardant properties meant that it could save lives, make buildings strong and make industries rich. It was first used by the Greeks some 2000 years ago. They were aware of the health hazards it posed but believed that its magical ability to withstand fire far outweighed this danger.

The dangers to health were all but ‘forgotten’ until at the turn of the twentieth century when medical researchers noticed a large number of deaths and lung problems occurring in asbestos mining towns. In 1917 and 1918, several United States studies discovered that asbestos workers were dying unnaturally young.

Asbestosis was first diagnosed in a 33 year old woman in 1924, this lead to studies being carried out on asbestos workers in the UK. Examinations on the workers showed that thirty percent had asbestos-related lung disease. UK laws were introduced in 1931 to increase ventilation and to make asbestosis an identifiable work related illness.

Despite the established link between asbestos and lung diseases the industry continued to grow well into the last century. At the peak of its usage asbestos was produced in 24 countries worldwide; it was also manufactured in over 100. World production climaxed at over 5 million tonnes. The building, shipping, insulation and demolition companies whose workers came into contact with asbestos were often aware that their staff were at risk. They did not take sufficient steps to protect their workforce from personal injury.

Sadly the effects of asbestos take many years to manifest themselves. People who worked in the construction industries some 20 to 40 years ago may still be awaiting their fate. Asbestos causes several diseases, two of which occur only in those who have had contact with asbestos, asbestosis and mesothelioma. Lung cancer and emphysema are more commonly associated with smoking but frequently occur in non smokers with a history of asbestos contact.

It is thought that the worst is yet to come. The peak of asbestos usage was in the 60’s and 70’s so many people may develop lung diseases in the near future.

Due to the latency of asbestos diseases it is thought that we will be seeing many more incidences of mesothelioma in the next 25 years. Hugh Robertson, head of health and safety at the British TUC says: "A realistic estimate is that within the EU alone 500,000 will die in the next 35 years, half from mesothelioma and half from lung cancer. In Japan, an estimated 100,000 will die. If you add the Australian, Canadian and US figures then even a million is an under estimation – and that is only for the developed countries.”

People affected by asbestos are entitled to compensation from the companies who knowingly exposed them many years ago.

Mesothelioma Survival

Malignant pleural mesothelioma is the most common type of malignant mesothelioma. Many factors may be involved in determining the survival rate for this aggressive cancer; some are better understood than others. Estimates of median survival time range from one to two years; survival depends on underlying factors such as the type and extent of spread of the mesothelioma. Only seven percent of people with this cancer survive to five years after diagnosis, but this outlook is gradually improving with some promising experimental treatments. Some people live well beyond five years from the time of diagnosis.

In general, younger age at diagnosis, absence of weight loss and limited loss of lung function are associated with chances for increased survival. Stage I mesotheliomas, which have not spread to the lymph nodes or adjacent tissues and organs, also carry the best prognosis. The type of cell the cancer is comprised of can also affect survival. The epithelioid cell type has the best prognosis, the mixed or biphasic cell type the next best prognosis, and the sarcomatoid cell type the worst prognosis. The majority of malignant pleural mesotheliomas are of the epithelioid cell type.

Because this cancer takes so long to manifest, people are usually diagnosed at an older age and with more advanced disease, potentially worsening the prognosis and the treatment options available. The more aggressive the treatment, the better the outcome may be, but in cases with cancer that has spread to other parts of the body, chemotherapy may be the only alternative. New drugs, such as the combination of Alimta with Platinol, have been shown to improve survival in malignant mesothelioma patients whose only option is chemotherapy. A number of experimental treatments, such as immunotherapy and biotherapy, are currently being evaluated in clinical trials.